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Cardioskeletal Mitochondrial Myopathy Associated with Chronic Magnesium Deficiency Neurol 42:128-130, Riggs,J.E.,et al, 1992 See this aricle in Pubmed Article Abstract A 3-year-old boy presenting with convulsions and carpopedal spasm had hypomagnesemia and hypermagnesuria due to congenital magnesium-losing neuropathy.Despite chronic oral and intermittent intravenous magnesium supplementation,he remained chronically hypomagnesemic.At age 4,he developed a progressive proximal myopathy and dilated hypertrophic cardiomyopathy that ultimately contributed to his death at age 14 years. Skeletal and cardiac muscle specimens showed a mitochondrial myopathy with increased numbers of enlarged,structurally abnormal mitochondria.Muscle magnesium content was markedly decreased.Chronic oral and intermittent intravenous magnesium supplementation may be inadequate to prevent the progressive cardioskeletal myopathy associated with the chronic magnesium deficiency of congenital magnesium-losing nephropathy.

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(click to filter results - removes previous filter) cardiomyopathy hypomagnesemia myopathy myopathy,mitochondrial myopathy,proximal

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